Standard Article

Quality Assurance in Analytical Chemistry

General Articles

  1. Christoph Fischbacher

Published Online: 15 SEP 2006

DOI: 10.1002/9780470027318.a8107

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Fischbacher, C. 2006. Quality Assurance in Analytical Chemistry. Encyclopedia of Analytical Chemistry. .

Author Information

  1. Analytik Jena AG, Jena, Germany

Publication History

  1. Published Online: 15 SEP 2006


Analytical methods have to meet certain quality requirements, so that the results are credible and can be used with confidence for regulatory, economic and research decisions. Analytical quality assurance (QA) contains preventive action and comprises planning steps, quality control (QC), quality assessment, documentation and quality improvement. All factors leading to the analytical result have to be controlled, clearly described and documented. Furthermore, the analytical result should be linked to the sample and related to reference materials (RMs) or measurement standards by an unbroken chain of traceability. Two elements are needed in order to achieve this goal: internal QA measures comprise elements performed by the laboratory, such as method validation and documentation and the use of RMs, external QA relates to performance evaluation by persons outside the laboratory, such as proficiency tests and accreditation.