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Ultrashort Laser-Pulse Medical Imaging

Biomedical Spectroscopy

  1. Moshe Ben-David,
  2. Reut Cohen,
  3. Osnat Harbater,
  4. Idan Steinberg,
  5. Michal Tepper,
  6. Israel Gannot

Published Online: 15 DEC 2010

DOI: 10.1002/9780470027318.a9002

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Ben-David, M., Cohen, R., Harbater, O., Steinberg, I., Tepper, M. and Gannot, I. 2010. Ultrashort Laser-Pulse Medical Imaging. Encyclopedia of Analytical Chemistry. .

Author Information

  1. Tel-Aviv University, Department of Biomedical Engineering, Tel-Aviv, Israel

Publication History

  1. Published Online: 15 DEC 2010

Abstract

Short-pulse tunable lasers are powerful tools that enable us to measure photon time of flight, lifetime changes, trigger processes, and operation in a nonionizing spectral range. Monochromatic X-ray radiation can also be achieved with the use of a free-electron laser (FEL). In this case, the amount of hazardous radiation is significantly lowered; however, the resolution is much higher. Therefore, FELs can serve as important tool for various imaging methods in vitro or in vivo. This article covers a few optical imaging methods such as optical tomography, optical coherence tomography (OCT), fluorescence lifetime imaging, FEL X-ray tomography for in vivo imaging, and coherent anti-Stokes Raman spectroscopy (CARS) for accurate chemical structures detection in live cells in vitro. All these imaging and spectral methods became possible only because of these lasers.