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Supramolecular Analytical Chemistry in Separation Techniques

Liquid Chromatography

  1. Ana Ballesteros-Gómez,
  2. María Dolores Sicilia,
  3. Soledad Rubio

Published Online: 15 DEC 2010

DOI: 10.1002/9780470027318.a9181

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Ballesteros-Gómez, A., Dolores Sicilia, M. and Rubio, S. 2010. Supramolecular Analytical Chemistry in Separation Techniques. Encyclopedia of Analytical Chemistry. .

Author Information

  1. University of Córdoba, Department of Analytical Chemistry, Córdoba, Spain

Publication History

  1. Published Online: 15 DEC 2010

Abstract

Supramolecular analytical chemistry is an emergent science covering the study and application of supramolecular systems (host molecules and molecular aggregates) in analytical processes. This article covers the progress on both theoretical and practical aspects related to the use of supramolecular systems in separation techniques reported over the last decade. Principles of supramolecular chemistry that allow a better understanding of the mechanisms of formation of the supramolecular entities and solubilization of solutes are outlined. Developments related to the use of supramolecular solvents and hemimicellar or admicellar sorbents in analytical extractions are critically discussed. Advances in the use of micelles in liquid chromatography (LC) and electrophoresis as well as developments in chiral chromatography and electrophoresis based on the use of cyclodextrins (CDs) and their derivatives are presented. Emphasis is placed on the strategies developed to make these techniques compatible with mass spectrometry (MS). The capability of supramolecular systems to effectively solubilize solutes in a wide polarity range is highlighted.

Keywords:

  • supramolecular analytical chemistry;
  • liquid chromatography;
  • gas chromatography;
  • capillary electrophoresis;
  • cyclodextrins;
  • supramolecular solvents;
  • hemimicelles/admicelles