10. Interactions of Cytochrome P450 with Nitric Oxide and Related Ligands

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Andrew W. Munro,
  2. Kirsty J. McLean and
  3. Hazel M. Girvan

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch10

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Munro, A. W., McLean, K. J. and Girvan, H. M. (2007) Interactions of Cytochrome P450 with Nitric Oxide and Related Ligands, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch10

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Manchester Interdisciplinary Biocentre, School of Chemical Engineering and Analytical Science, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • ligand and substrate interactions with p450 enzymes;
  • nitric oxide interactions with P450s;
  • cytochromes P450 - superfamily of heme b-containing oxygenases;
  • P450 nor (CYP55A1);
  • F. oxysporum P450 nor;
  • azoles as P450 inhibitors;
  • carbon monoxide binding to P450s;
  • P450 suicide inhibitors

Summary

This chapter contains sections titled:

  • Introduction. Interactions of Ligands and Substrates with P450 Enzymes: General Features

  • Nitric Oxide and Its Interactions with P450s

  • Interactions of Imidazoles and Substituted Imidazoles with P450s

  • Other Ligands and Inhibitors of P450 Function

  • Conclusions and Future Prospects

  • Acknowledgments

  • Abbreviations

  • References