11. Cytochrome P450-Catalyzed Hydroxylations and Epoxidations

  1. Astrid Sigel3,
  2. Helmut Sigel3 and
  3. Roland K. O. Sigel4
  1. Roshan Perera1,
  2. Shengxi Jin1,
  3. Masanori Sono1 and
  4. John H. Dawson2

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch11

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Perera, R., Jin, S., Sono, M. and Dawson, J. H. (2007) Cytochrome P450-Catalyzed Hydroxylations and Epoxidations, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch11

Editor Information

  1. 3

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 4

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA

  2. 2

    Department of Chemistry and Biochemistry, and School of Medicine, University of South Carolina, Columbia, SC 29208, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • cytochrome P450 enzymes;
  • cytochrome P450 catalytic reaction cycle;
  • P450-catalyzed hydroxylations and epoxidations;
  • oxyferrous heme iron intermediate;
  • p450 multiple mechanism catalysis;
  • hydroxylation mechanism;
  • multiple oxidants in P450 catalysis;
  • two states theory

Summary

This chapter contains sections titled:

  • Introduction

  • The Cytochrome P450 Enzymes

  • Three-Dimensional Structures of the Active Sites of Cytochrome P450 Enzymes

  • Role of the Cys Ligand: the Proximal Thiolate ‘Push’ and Distal Proton-Delivery

  • Multiple Mechanisms of P450 Catalysis

  • Multiple Oxidants in P450 Catalysis

  • Two States Theory

  • Influence of Substrate on the Spectral Properties and Reactivity of P450 Intermediates

  • Formation and Reactivity of Transient P450 Oxygen Intermediates

  • Summary and Future Prospective

  • Acknowledgments

  • Abbreviations

  • References