11. Cytochrome P450-Catalyzed Hydroxylations and Epoxidations
- Astrid Sigel3,
- Helmut Sigel3,
- Roland K. O. Sigel4
Published Online: 11 MAY 2007
DOI: 10.1002/9780470028155.ch11
Copyright © 2007 John Wiley & Sons, Ltd
Book Title
The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3
Additional Information
How to Cite
Perera, R., Jin, S., Sono, M. and Dawson, J. H. (2007) Cytochrome P450-Catalyzed Hydroxylations and Epoxidations, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch11
Editor Information
- 3
Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland
- 4
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Publication History
- Published Online: 11 MAY 2007
- Published Print: 23 MAR 2007
ISBN Information
Print ISBN: 9780470016725
Online ISBN: 9780470028155
- Summary
- Chapter
Keywords:
- cytochrome P450 enzymes;
- cytochrome P450 catalytic reaction cycle;
- P450-catalyzed hydroxylations and epoxidations;
- oxyferrous heme iron intermediate;
- p450 multiple mechanism catalysis;
- hydroxylation mechanism;
- multiple oxidants in P450 catalysis;
- two states theory
Summary
This chapter contains sections titled:
Introduction
The Cytochrome P450 Enzymes
Three-Dimensional Structures of the Active Sites of Cytochrome P450 Enzymes
Role of the Cys Ligand: the Proximal Thiolate ‘Push’ and Distal Proton-Delivery
Multiple Mechanisms of P450 Catalysis
Multiple Oxidants in P450 Catalysis
Two States Theory
Influence of Substrate on the Spectral Properties and Reactivity of P450 Intermediates
Formation and Reactivity of Transient P450 Oxygen Intermediates
Summary and Future Prospective
Acknowledgments
Abbreviations
References