14. Design and Engineering of Cytochrome P450 Systems

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Stephen G. Bell,
  2. Nicola Hoskins,
  3. Christopher J. C. Whitehouse and
  4. Luet L. Wong

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch14

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Bell, S. G., Hoskins, N., Whitehouse, C. J. C. and Wong, L. L. (2007) Design and Engineering of Cytochrome P450 Systems, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch14

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Department of Chemistry, Inorganic Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QR, UK

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • P450 enzyme activity;
  • engineering bacterial cytochrome P450 systems;
  • engineering mammalian cytochrome P450 enzymes;
  • engineering P450 enzymes;
  • directed evolution;
  • human CYP11B1 and CYP11B2 enzymes;
  • engineering plant P450 enzymes;
  • re-engineering substrate specificity and selectivity

Summary

This chapter contains sections titled:

  • Introduction

  • Engineering Bacterial Cytochrome P450 Systems

  • Engineering Mammalian Cytochrome P450 Enzymes

  • Engineering Plant P450 Enzymes

  • Conclusions and Outlook

  • Abbreviations

  • References