16. Drug Metabolism as Catalyzed by Human Cytochrome P450 Systems

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. F. Peter Guengerich

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch16

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Guengerich, F. P. (2007) Drug Metabolism as Catalyzed by Human Cytochrome P450 Systems, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch16

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 23rd & Pierce Avenues, Nashville, TN 37232-0146, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • drug metabolism P450 enzymes;
  • drug-drug interactions;
  • predicting P450 activity in humans;
  • major P450s in drug metabolism;
  • other P450s and drug metabolism;
  • drug-drug interactions;
  • major human P450s determined using X-ray crystallography

Summary

This chapter contains sections titled:

  • Introduction

  • Importance of P450 Enzymes in Drug Metabolism

  • Approaches to Predicting P450 Activity in Humans

  • P450s Involved in Drug Metabolism

  • Examples of Major Issues Involving Drug Metabolism by P450

  • Summary

  • Acknowledgments

  • Abbreviations

  • References