17. Cytochrome P450 Enzymes: Observations from the Clinic

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Peggy L. Carver

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch17

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Carver, P. L. (2007) Cytochrome P450 Enzymes: Observations from the Clinic, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch17

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. University of Michigan College of Pharmacy, Clinical Sciences Department, 428 Church St., Ann Arbor, MI 48109-1065, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • cytochrome p450 enzyme drug metabolism;
  • cytochrome P450 (CYP) clinical significance;
  • cytochrome P450 enzymes;
  • CYP3A and interindividual variability in activity;
  • CYP inhibition and drug adverse effects;
  • genetic polymorphism;
  • CYP isoform catalytic activity and phenotyping with in vivo probe;
  • CYP herbal and dietary effects

Summary

This chapter contains sections titled:

  • Introduction

  • Drug Interactions

  • Drug Metabolism by Cytochrome P450 Enzymes

  • Alterations in P450 Enzymes

  • Active Transport of Drugs

  • Enzyme-Transporter Cooperativity

  • Use of Probes to Quantitate CYP Activity in Humans

  • Prodrugs

  • The Effect of Intravenous Versus Oral Administration on Drug Interactions

  • Additional Factors Affecting Drug Interactions

  • Herbal and Dietary Effects on CYP

  • Interactions with Commonly Used Medications

  • Beneficial Effects of Drug Interactions

  • FDA Regulations Regarding CYP450-Mediated Drug Interactions

  • Clinical Significance of Drug Interactions

  • Summary

  • Acknowledgment

  • Abbreviations

  • References