17. Cytochrome P450 Enzymes: Observations from the Clinic
- Astrid Sigel2,
- Helmut Sigel2,
- Roland K. O. Sigel3
Published Online: 11 MAY 2007
DOI: 10.1002/9780470028155.ch17
Copyright © 2007 John Wiley & Sons, Ltd
Book Title
The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3
Additional Information
How to Cite
Carver, P. L. (2007) Cytochrome P450 Enzymes: Observations from the Clinic, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch17
Editor Information
- 2
Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland
- 3
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Publication History
- Published Online: 11 MAY 2007
- Published Print: 23 MAR 2007
ISBN Information
Print ISBN: 9780470016725
Online ISBN: 9780470028155
- Summary
- Chapter
Keywords:
- cytochrome p450 enzyme drug metabolism;
- cytochrome P450 (CYP) clinical significance;
- cytochrome P450 enzymes;
- CYP3A and interindividual variability in activity;
- CYP inhibition and drug adverse effects;
- genetic polymorphism;
- CYP isoform catalytic activity and phenotyping with in vivo probe;
- CYP herbal and dietary effects
Summary
This chapter contains sections titled:
Introduction
Drug Interactions
Drug Metabolism by Cytochrome P450 Enzymes
Alterations in P450 Enzymes
Active Transport of Drugs
Enzyme-Transporter Cooperativity
Use of Probes to Quantitate CYP Activity in Humans
Prodrugs
The Effect of Intravenous Versus Oral Administration on Drug Interactions
Additional Factors Affecting Drug Interactions
Herbal and Dietary Effects on CYP
Interactions with Commonly Used Medications
Beneficial Effects of Drug Interactions
FDA Regulations Regarding CYP450-Mediated Drug Interactions
Clinical Significance of Drug Interactions
Summary
Acknowledgment
Abbreviations
References