3. Structures of P450 Proteins and Their Molecular Phylogeny

  1. Astrid Sigel2,
  2. Helmut Sigel2,
  3. Roland K. O. Sigel3
  1. Thomas L. Poulos,
  2. Yergalem T. Meharenna

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Poulos, T. L. and Meharenna, Y. T. (2007) Structures of P450 Proteins and Their Molecular Phylogeny, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch3

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Department of Biochemistry and Molecular Biology, Physiology and Biophysics, and Chemistry, University of California, Irvine, CA 92697-3900, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • P450 families and subfamilies;
  • P450 evolution;
  • P450 protein molecular phylogeny;
  • P450 families and CYPXXX;
  • novel P450-like proteins;
  • P450s and structure-based inhibitor/drug design challenges;
  • P450 chemistry as industrial and medical intermediates

Summary

This chapter contains sections titled:

  • Introduction

  • P450 Evolution

  • P450 Families and Subfamilies

  • P450 Structures

  • Variation in P450 Function and Fold

  • Archaeon P450s

  • Summary and Conclusions

  • Acknowledgments

  • Abbreviations

  • References