3. Structures of P450 Proteins and Their Molecular Phylogeny

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Thomas L. Poulos and
  2. Yergalem T. Meharenna

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Poulos, T. L. and Meharenna, Y. T. (2007) Structures of P450 Proteins and Their Molecular Phylogeny, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch3

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Department of Biochemistry and Molecular Biology, Physiology and Biophysics, and Chemistry, University of California, Irvine, CA 92697-3900, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • P450 families and subfamilies;
  • P450 evolution;
  • P450 protein molecular phylogeny;
  • P450 families and CYPXXX;
  • novel P450-like proteins;
  • P450s and structure-based inhibitor/drug design challenges;
  • P450 chemistry as industrial and medical intermediates

Summary

This chapter contains sections titled:

  • Introduction

  • P450 Evolution

  • P450 Families and Subfamilies

  • P450 Structures

  • Variation in P450 Function and Fold

  • Archaeon P450s

  • Summary and Conclusions

  • Acknowledgments

  • Abbreviations

  • References