7. Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Christiane Jung

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch7

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Jung, C. (2007) Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch7

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Max-Delbrück Center for Molecular Medicine, Research Group Protein Dynamics, D-13125 Berlin, Germany

  1. Present address: KKS Ultraschall AG, Surface Treatment Division, Frauholzring 29, CH-6422 Steinen, SZ, Switzerland

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • protein structural parameters;
  • cytochrome P450 reaction cycle;
  • cytochrome P450 leakage reaction;
  • P450cam-Pdx interaction;
  • P450 iron-oxo intermediate;
  • Caldariomyces fumago (CPO);
  • protein radical formation leakage;
  • EPR and Mössbauer analysis and P450 reaction mechanism

Summary

This chapter contains sections titled:

  • Introduction

  • Protein Structural Parameters

  • The Reaction Cycle of Cytochrome P450

  • Protein Structural Parameters and Extent of Competitive Reactions

  • Concluding Remarks

  • Acknowledgments

  • Abbreviations

  • References