8. Cytochromes P450 – Structural Basis for Binding and Catalysis

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Konstanze von König and
  2. Ilme Schlichting

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch8

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

von König, K. and Schlichting, I. (2007) Cytochromes P450 – Structural Basis for Binding and Catalysis, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch8

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

SEARCH

Keywords:

  • cytochrome P450 enzymes;
  • P450 structural basis for binding and catalysis;
  • CYP101 architecture;
  • distal acid-alcohol pair;
  • wild-type and mutant CYP107A;
  • CYP158A2 substrate specificity;
  • proton transfer via proton relay system

Summary

This chapter contains sections titled:

  • Introduction

  • Ligand Binding: Substrate Recognition and Access to the Distal Pocket

  • Architecture of the Active Site of CYP101

  • The Distal Acid-Alcohol Pair

  • Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions

  • Crystal Structures of Oxy-Ferrous Complexes

  • Mechanism: Summary, Conclusions, Speculations

  • Acknowledgments

  • Abbreviations

  • References