8. Cytochromes P450 – Structural Basis for Binding and Catalysis
- Astrid Sigel2,
- Helmut Sigel2,
- Roland K. O. Sigel3
Published Online: 11 MAY 2007
DOI: 10.1002/9780470028155.ch8
Copyright © 2007 John Wiley & Sons, Ltd
Book Title
The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3
Additional Information
How to Cite
von König, K. and Schlichting, I. (2007) Cytochromes P450 – Structural Basis for Binding and Catalysis, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch8
Editor Information
- 2
Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland
- 3
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Publication History
- Published Online: 11 MAY 2007
- Published Print: 23 MAR 2007
ISBN Information
Print ISBN: 9780470016725
Online ISBN: 9780470028155
- Summary
- Chapter
Keywords:
- cytochrome P450 enzymes;
- P450 structural basis for binding and catalysis;
- CYP101 architecture;
- distal acid-alcohol pair;
- wild-type and mutant CYP107A;
- CYP158A2 substrate specificity;
- proton transfer via proton relay system
Summary
This chapter contains sections titled:
Introduction
Ligand Binding: Substrate Recognition and Access to the Distal Pocket
Architecture of the Active Site of CYP101
The Distal Acid-Alcohol Pair
Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions
Crystal Structures of Oxy-Ferrous Complexes
Mechanism: Summary, Conclusions, Speculations
Acknowledgments
Abbreviations
References