9. Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems

  1. Astrid Sigel3,
  2. Helmut Sigel3,
  3. Roland K. O. Sigel4
  1. Yi Lu1,
  2. Thomas D. Pfister2

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch9

Book Title

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

Additional Information

How to Cite

Lu, Y. and Pfister, T. D. (2007) Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch9

Editor Information

  1. 3

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 4

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Department of Biochemistry and Department of Chemistry, University of Illinois at Urbana-Champaign, A322 Chemical and Life Science Building, Box 8-6, 600 S. Matthews Avenue, Urbana, IL 61801, USA

  2. 2

    Department of Biochemistry, University of Illinois at Urbana-Champaign, A322 Chemical and Life Science Building, Box 8-6, 600 S. Matthews Avenue, Urbana, IL 61801, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • cytochrome P450 (P450) active site;
  • co-sensing transcriptional activator (COOA) and heme-thiolate ligation;
  • secondary sphere interaction role in P450s;
  • synthetic model complexes to mimic active site of P450;
  • heme-thiolate ligation;
  • dioxygen cleavage using hydrogen-bonding network;
  • secondary coordination sphere

Summary

This chapter contains sections titled:

  • Overview of Cytochrome P450 Active Site Structure

  • Secondary Coordination Sphere on the Proximal Side

  • Secondary Coordination Sphere on the Distal Side

  • Summary and Outlook

  • Acknowledgments

  • Abbreviations

  • References

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