9. Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems

  1. Astrid Sigel3,
  2. Helmut Sigel3 and
  3. Roland K. O. Sigel4
  1. Yi Lu1 and
  2. Thomas D. Pfister2

Published Online: 11 MAY 2007

DOI: 10.1002/9780470028155.ch9

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3

How to Cite

Lu, Y. and Pfister, T. D. (2007) Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems, in The Ubiquitous Roles of Cytochrome P450 Proteins, Volume 3 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470028155.ch9

Editor Information

  1. 3

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 4

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Department of Biochemistry and Department of Chemistry, University of Illinois at Urbana-Champaign, A322 Chemical and Life Science Building, Box 8-6, 600 S. Matthews Avenue, Urbana, IL 61801, USA

  2. 2

    Department of Biochemistry, University of Illinois at Urbana-Champaign, A322 Chemical and Life Science Building, Box 8-6, 600 S. Matthews Avenue, Urbana, IL 61801, USA

Publication History

  1. Published Online: 11 MAY 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470016725

Online ISBN: 9780470028155

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Keywords:

  • cytochrome P450 (P450) active site;
  • co-sensing transcriptional activator (COOA) and heme-thiolate ligation;
  • secondary sphere interaction role in P450s;
  • synthetic model complexes to mimic active site of P450;
  • heme-thiolate ligation;
  • dioxygen cleavage using hydrogen-bonding network;
  • secondary coordination sphere

Summary

This chapter contains sections titled:

  • Overview of Cytochrome P450 Active Site Structure

  • Secondary Coordination Sphere on the Proximal Side

  • Secondary Coordination Sphere on the Distal Side

  • Summary and Outlook

  • Acknowledgments

  • Abbreviations

  • References