Chapter 6. Whole or Partial Vessel Outgrowth Assays

  1. Carolyn A. Staton2,3,
  2. Claire Lewis4 and
  3. Roy Bicknell5
  1. Cindy H. Chau and
  2. William D. Figg

Published Online: 27 SEP 2007

DOI: 10.1002/9780470029350.ch6

Angiogenesis Assays: A Critical Appraisal of Current Techniques

Angiogenesis Assays: A Critical Appraisal of Current Techniques

How to Cite

Chau, C. H. and Figg, W. D. (2006) Whole or Partial Vessel Outgrowth Assays, in Angiogenesis Assays: A Critical Appraisal of Current Techniques (eds C. A. Staton, C. Lewis and R. Bicknell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470029350.ch6

Editor Information

  1. 2

    Academic Unit of Surgical Oncology, University of Sheffield Medical School, Sheffield, UK

  2. 3

    Academic Unit of Surgical Oncology, K-Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK

  3. 4

    Academic Unit of Pathology, University of Sheffield Medical School, Sheffield, UK

  4. 5

    Division of Immunity and Infection, University of Birmingham, Birmingham, UK

Author Information

  1. Molecular Pharmacology Section, Medical Oncology Branch, Centre for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

Publication History

  1. Published Online: 27 SEP 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9780470016008

Online ISBN: 9780470029350

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Keywords:

  • aortic ring assay;
  • whole or partial vessel outgrowth assays;
  • chick aortic arch assay;
  • human explant cultures;
  • angiogenesis quantification in organ culture assays;
  • aortic ring organ-culture system;
  • microarray technology;
  • quantitative angiogenic assays

Summary

This chapter contains sections titled:

  • Introduction

  • Rat aortic ring assay

  • Mouse aorta models

  • Chick aortic arch assay

  • Porcine carotid artery assay

  • Human explant cultures

  • Recent developments

  • Quantification

  • Strengths and weaknesses of organ culture assays

  • Applications

  • Conclusions

  • References