Chapter 8. Glycosylation of Proteins

  1. Claus-Wilhelm von der Lieth1,
  2. Thomas Lütteke2 and
  3. Martin Frank1
  1. Claus-Wilhelm von der Lieth1 and
  2. Thomas Lütteke2

Published Online: 13 NOV 2009

DOI: 10.1002/9780470029619.ch8

Bioinformatics for Glycobiology and Glycomics: An Introduction

Bioinformatics for Glycobiology and Glycomics: An Introduction

How to Cite

von der Lieth, C.-W. and Lütteke, T. (2009) Glycosylation of Proteins, in Bioinformatics for Glycobiology and Glycomics: An Introduction (eds C.-W. von der Lieth, T. Lütteke and M. Frank), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470029619.ch8

Editor Information

  1. 1

    Molecular Structure Analysis Core Facility, Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Germany

  2. 2

    Faculty of Veterinary Medicine, Institute of Biochemistry and Endocrinology, Justus-Liebig University Gießen, Gießen, Germany

Author Information

  1. 1

    Molecular Structure Analysis Core Facility, Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Germany

  2. 2

    Faculty of Veterinary Medicine, Institute of Biochemistry and Endocrinology, Justus-Liebig University Gießen, Gießen, Germany

Publication History

  1. Published Online: 13 NOV 2009
  2. Published Print: 11 DEC 2009

ISBN Information

Print ISBN: 9780470016671

Online ISBN: 9780470029619

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Keywords:

  • Protein glycosylation;
  • N-Glycosylation;
  • O-Glycosylation;
  • Glycosylation site;
  • Glycoprotein;
  • Carbohydrate;
  • Statistical analysis

Summary

Glycosylation is the most common and most complex co- and posttranslational modification of proteins. Glycan chains can alter the physico-chemical properties of glycoproteins, and N-glycans also play an important role in the protein folding process. Glycosylated proteins on cell surfaces are implicated in various cell-cell and cell-matrix interactions. This chapter gives an overview of the various glycosylation types, and the functions and biosynthesis of the carbohydrate chains. A statistical analysis of the amino acids in the neighborhood of occupied glycosylation sites reveals different patterns of frequently found amino acids around N-glycosylation and O-glycosylation sites.