Ectonucleotidases in the Nervous System

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Herbert Zimmermann

Published Online: 7 OCT 2008

DOI: 10.1002/9780470032244.ch10

Purinergic Signalling in Neuron-Glia Interactions: Novartis Foundation Symposium 276

Purinergic Signalling in Neuron-Glia Interactions: Novartis Foundation Symposium 276

How to Cite

Zimmermann, H. (2006) Ectonucleotidases in the Nervous System, in Purinergic Signalling in Neuron-Glia Interactions: Novartis Foundation Symposium 276 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470032244.ch10

Author Information

  1. Biozentrum der J.W. Goethe-Universität, AK Neurochemie, Marie-Curie-Str. 9, D-60439 Frankfurt am Main, Germany

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 21 APR 2006

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470018606

Online ISBN: 9780470032244

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Keywords:

  • ectonucleotidases and extracellular nucleotide hydrolysis;
  • E-NTPDase (ectonucleoside triphosphate diphosphohydrolase) family;
  • NAD-metabolizing ecto-enzymes;
  • ectonucleotidases in adult neurogenesis;
  • ectonucleotidases and purinergic signalling

Summary

Extracellular nucleotides are hydrolysed by enzymes of the plasma membrane with an extracellularly oriented catalytic site (ectonucleotidases). Members of several families of ectonucleotidases can contribute to extracellular nucleotide hydrolysis. They have been characterized in molecular and functional terms. A major role of these enzymes is in the modulation of ligand availability at nucleotide and nucleoside receptors. The enzymes reveal a wide and partially overlapping tissue distribution. The diversity of the individual family members is considerable and it is still difficult to assign identified enzymes to the modulation of purinergic signalling pathways. In the brain, members of all ectonucleotidase families are expressed. Proposed physiological functions include modulation of synaptic transmission, of the ATP-mediated propagation of glial Ca2+waves, of microglial function, adult neurogenesis or the control of vascular tone, haemostasis and thromboregulation.