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Metallo-Enzymes and Metallo-Proteins, Chemistry of

  1. Robert J.P. Williams

Published Online: 15 MAY 2008

DOI: 10.1002/9780470048672.wecb327

Wiley Encyclopedia of Chemical Biology

Wiley Encyclopedia of Chemical Biology

How to Cite

Williams, R. J. 2008. Metallo-Enzymes and Metallo-Proteins, Chemistry of. Wiley Encyclopedia of Chemical Biology. 1–8.

Author Information

  1. Oxford University, Oxford, United Kingdom

Publication History

  1. Published Online: 15 MAY 2008


Metallo-enzymes and metallo-proteins are a combination of a metal ion or several metal ions in which the metal ion is strongly held in a protein. Hence, before describing their properties and functions, it is necessary to appreciate which metal ions bind strongly to proteins and exchange slowly. The biological significance of metallo-enzymes is that they are essential catalysts, especially for the metabolism of small molecules such as H2, CH4, CO, N2, and O2, as well as for long-range electron transfer. The control of uptake and the synthesis of their proteins rest with feedback in a series of metallo-proteins.