Standard Article

Dose Calibration

Environmental Health

  1. Marie Davidian

Published Online: 15 SEP 2006

DOI: 10.1002/9780470057339.vad038

Encyclopedia of Environmetrics

Encyclopedia of Environmetrics

How to Cite

Davidian, M. 2006. Dose Calibration. Encyclopedia of Environmetrics. 2.

Author Information

  1. North Carolina State University, NC, USA

Publication History

  1. Published Online: 15 SEP 2006

Abstract

Calibration refers broadly to the determination of a variable x on the basis of measurement(s) on another variable y. In the dose calibration problem, x is the unknown level (concentration, dose) of antigen (enzyme, hormone, protein, compound) in a biological test sample to be determined from y. It may be infeasible to determine x directly from the specimen, but the specimen may be subjected to an assay procedure that yields an associated measurement y. Given an understanding of the relationship between x and y, x may be estimated. Such calibration is commonplace in environmental health studies. Toxicokinetic modeling for estimation of internal doses and validation of mechanistic hypotheses is a popular approach in characterizing the health effects of environmental exposures; underlying such studies is the need for precise calibration of levels of exposure agents and their metabolites from blood or other samples.