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Mutagenesis, Environmental

Environmental Health

  1. Walter W. Piegorsch

Published Online: 15 JAN 2013

DOI: 10.1002/9780470057339.vam051.pub2

Encyclopedia of Environmetrics

Encyclopedia of Environmetrics

How to Cite

Piegorsch, W. W. 2013. Mutagenesis, Environmental . Encyclopedia of Environmetrics. 4.

Author Information

  1. University of Arizona, Tucson, AZ, USA

Publication History

  1. Published Online: 15 JAN 2013

Abstract

Environmetric methods are discussed for analyzing data from mutagenicity bioassays. Emphasis is placed on the “gold-standard” microbial test system in environmental mutagenesis: the Ames/Salmonella microsome assay. The assay produces count data to quantify the mutational response; statistical issues of interest when analyzing such data include testing for extra-Poisson variability, trend testing for a dose response, and trend testing under a nonmonotone dose response.

Keywords:

  • Cochran-Armitage trend test;
  • DNA damage;
  • generalized score statistic;
  • mutagenesis;
  • overdispersion;
  • umbrella alternatives