Published Online: 15 JAN 2013
Copyright © 2002 John Wiley & Sons, Ltd
Encyclopedia of Environmetrics
How to Cite
Piegorsch, W. W. 2013. Mutagenesis, Environmental . Encyclopedia of Environmetrics. 4.
- Published Online: 15 JAN 2013
Environmetric methods are discussed for analyzing data from mutagenicity bioassays. Emphasis is placed on the “gold-standard” microbial test system in environmental mutagenesis: the Ames/Salmonella microsome assay. The assay produces count data to quantify the mutational response; statistical issues of interest when analyzing such data include testing for extra-Poisson variability, trend testing for a dose response, and trend testing under a nonmonotone dose response.
- Cochran-Armitage trend test;
- DNA damage;
- generalized score statistic;
- umbrella alternatives