Standard Article

Neurotoxicology, Environmental

Environmental Health

  1. Paul J. Catalano1,2

Published Online: 15 JAN 2013

DOI: 10.1002/9780470057339.van014.pub2

Encyclopedia of Environmetrics

Encyclopedia of Environmetrics

How to Cite

Catalano, P. J. 2013. Neurotoxicology, Environmental . Encyclopedia of Environmetrics. 4.

Author Information

  1. 1

    Dana-Farber Cancer Institute, Boston, MA, USA

  2. 2

    Harvard School of Public Health, Boston, MA, USA

Publication History

  1. Published Online: 15 JAN 2013


Neurotoxicity testing is an important area of noncancer toxicity evaluation. This article provides a description of the functional observational battery (FOB), a frequently employed neurobehavioral assessment, and discusses some of the statistical and data analytical issues surrounding its analysis. Emphasis is given to describing the multivariate nature of the FOB data.


  • multiple outcomes;
  • binary data;
  • ordinal data;
  • dose-response;
  • risk estimation;
  • screening assay