Standard Article

Transmission/Disequilibrium Test

Environmental Health

  1. Françoise Seillier-moiseiwitsch1,
  2. Tianhua Niu2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470057339.vat020m

Encyclopedia of Environmetrics

Encyclopedia of Environmetrics

How to Cite

Seillier-moiseiwitsch, F. and Niu, T. 2006. Transmission/Disequilibrium Test. Encyclopedia of Environmetrics. 6.

Author Information

  1. 1

    University of North Carolina at Chapel Hill, NC, USA

  2. 2

    Harvard University, MA, USA

Publication History

  1. Published Online: 15 SEP 2006


The transmission/disequilibrium test (TDT) can be utilized as a test of linkage between a marker and a disease locus or as a test of association between these loci. It relies on the marker information from triads consisting of parents and their affected child. Its properties depend on the purpose it is used for. Its validity for stratified populations makes it particularly attractive. Also, it is often more powerful than allele-sharing methods for complex diseases.