Standard Article

Up-and-Down Designs

Statistical Theory and Methods

  1. Nancy Flournoy1,2,
  2. Assaf P. Oron1,2

Published Online: 15 JAN 2013

DOI: 10.1002/9780470057339.vau004.pub2

Encyclopedia of Environmetrics

Encyclopedia of Environmetrics

How to Cite

Flournoy, N. and P. Oron, A. 2013. Up-and-Down Designs . Encyclopedia of Environmetrics. 6.

Author Information

  1. 1

    University of Missouri, Columbia, MO, USA

  2. 2

    University of Washington, WA, USA

Publication History

  1. Published Online: 15 JAN 2013


Up-and-down designs are useful for evaluating and comparing the toxicity of pesticides and other chemical compounds. In particular, the primary goal of an up-and-down design in toxicity studies is to estimate the dose having a prespecified toxicity rate Γ,0 < Γ < 1. A secondary goal is to limit the experimental subjects that are given highly toxic exposure. Up-and-down designs can be sequential or group sequential.