Statistical Theory and Methods
Published Online: 15 JAN 2013
Copyright © 2002 John Wiley & Sons, Ltd
Encyclopedia of Environmetrics
How to Cite
Flournoy, N. and P. Oron, A. 2013. Up-and-Down Designs . Encyclopedia of Environmetrics. 6.
- Published Online: 15 JAN 2013
Up-and-down designs are useful for evaluating and comparing the toxicity of pesticides and other chemical compounds. In particular, the primary goal of an up-and-down design in toxicity studies is to estimate the dose having a prespecified toxicity rate Γ,0 < Γ < 1. A secondary goal is to limit the experimental subjects that are given highly toxic exposure. Up-and-down designs can be sequential or group sequential.