Chapter 16. Combining Quantitative Trait and Gene-Expression Data

  1. Michael R. Barnes
  1. Elissa J. Chesler

Published Online: 21 MAR 2007

DOI: 10.1002/9780470059180.ch16

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, Second Edition

Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, Second Edition

How to Cite

Chesler, E. J. (2007) Combining Quantitative Trait and Gene-Expression Data, in Bioinformatics for Geneticists: A Bioinformatics Primer for the Analysis of Genetic Data, Second Edition (ed M. R. Barnes), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470059180.ch16

Editor Information

  1. Bioinformatics, GlaxoSmithKline Pharmaceuticals, Third Avenue, Harlow, Essex, UK

Author Information

  1. Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, TN, USA

Publication History

  1. Published Online: 21 MAR 2007
  2. Published Print: 9 MAR 2007

ISBN Information

Print ISBN: 9780470026199

Online ISBN: 9780470059180

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Keywords:

  • combining quantitative trait and gene-expression data;
  • data transformations and mapping quality;
  • genetic analysis and mapping models;
  • systems genetic analysis;
  • expression QTL analysis

Summary

This chapter contains sections titled:

  • Introduction: the genetic regulation of endophenotypes

  • Transcript abundance as a complex phenotype

  • Scaling up genetic analysis and mapping models for microarrays

  • Genetic correlation analysis

  • Systems genetic analysis

  • Using expression QTLs to identify candidate genes for the regulation of complex phenotypes

  • Conclusions

  • References