Chapter 10. Nerve Agents: Low-Dose Effects

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath2,3,4,
  2. Robert L. Maynard CBE, FRCP, FRCPath5 and
  3. Frederick R. Sidell MD6
  1. Leah Scott

Published Online: 2 APR 2007

DOI: 10.1002/9780470060032.ch10

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

How to Cite

Scott, L. (2007) Nerve Agents: Low-Dose Effects, in Chemical Warfare Agents: Toxicology and Treatment, Second Edition (eds T. C. Marrs, R. L. Maynard and F. R. Sidell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470060032.ch10

Editor Information

  1. 2

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 3

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 4

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

  4. 5

    Health Protection Agency, Chilton, Didcot, Oxfordshire OX11 0RQ, UK

  5. 6

    US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA

Author Information

  1. Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

Publication History

  1. Published Online: 2 APR 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470013595

Online ISBN: 9780470060032



  • nerve agent exposure in man;
  • inhibition of cholinesterase - OP pesticides and nerve agents;
  • nerve agents and low-dose effects;
  • nerve agents sequelae of poisoning;
  • OP compound acute toxicity


This chapter contains sections titled:

  • Introduction

  • Animal Studies: General Considerations

  • Animal Studies: Short-Term Effects of Low Doses

  • Animal Studies: Long-Term Effects of Low Doses

  • Summary and Way Forward

  • References