Chapter 15. Oximes

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath3,4,5,
  2. Robert L. Maynard CBE, FRCP, FRCPath6 and
  3. Frederick R. Sidell MD7
  1. Peter A. Eyer1 and
  2. Franz Worek2

Published Online: 2 APR 2007

DOI: 10.1002/9780470060032.ch15

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

How to Cite

Eyer, P. A. and Worek, F. (2007) Oximes, in Chemical Warfare Agents: Toxicology and Treatment, Second Edition (eds T. C. Marrs, R. L. Maynard and F. R. Sidell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470060032.ch15

Editor Information

  1. 3

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 4

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 5

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

  4. 6

    Health Protection Agency, Chilton, Didcot, Oxfordshire OX11 0RQ, UK

  5. 7

    US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA

Author Information

  1. 1

    Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians University, Goethestrasse 33, D-80336 Munich, Germany

  2. 2

    Bundeswehr Institute of Pharmacology and Toxicology, University of Munich, Neuherbergstrasse 11, D-80937 Munich, Germany

Publication History

  1. Published Online: 2 APR 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470013595

Online ISBN: 9780470060032

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Keywords:

  • oxime history development;
  • 2-pyridine aldoxime methiodide (2-PAM);
  • site-directed mutagenesis and computational modelling;
  • oximes against nerve agents in animals in vivo;
  • pyridinium oxime pharmacokinetics

Summary

This chapter contains sections titled:

  • Introduction

  • History of Oxime Development

  • Mechanism of Oxime Action

  • Kinetics of Oxime-Induced Reactivation of Human Ache In Vitro

  • Efficacy of Oximes Against Nerve Agents in Animals In Vivo

  • Efficacy of Oximes Against Nerve Agents in Humans In Vivo

  • Stability of Oximes and Pharmaceutical Aspects

  • Metabolism and Excretion

  • Safety and Tolerability of Therapeutic Oximes

  • Assessment of Therapeutic Oxime Effects by Theoretical Models

  • Conclusions

  • References