Chapter 17. Pretreatment for Nerve Agent Poisoning

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath2,3,4,
  2. Robert L. Maynard CBE, FRCP, FRCPath5 and
  3. Frederick R. Sidell MD6
  1. Leah Scott

Published Online: 2 APR 2007

DOI: 10.1002/9780470060032.ch17

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

How to Cite

Scott, L. (2007) Pretreatment for Nerve Agent Poisoning, in Chemical Warfare Agents: Toxicology and Treatment, Second Edition (eds T. C. Marrs, R. L. Maynard and F. R. Sidell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470060032.ch17

Editor Information

  1. 2

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 3

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 4

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

  4. 5

    Health Protection Agency, Chilton, Didcot, Oxfordshire OX11 0RQ, UK

  5. 6

    US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA

Author Information

  1. Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

Publication History

  1. Published Online: 2 APR 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470013595

Online ISBN: 9780470060032



  • pretreatments in nerve agent poisoning;
  • pyridostigmine pretreatment;
  • pyridostigmine pretreatment acceptability;
  • physostigmine and hyoscine pretreatment;
  • pretreatment approach comparison


This chapter contains sections titled:

  • Introduction

  • Pretreatment with Pyridostigmine

  • Effectiveness of Pyridostigmine Pretreatment

  • Practicability of Pyridostigmine as a Pretreatment

  • Acceptability of Pyridostigmine Pretreatment

  • Future Prospects: Pretreatment with Physostigmine and Hyoscine

  • Effectiveness of Physostigmine/Hyoscine Pretreatment

  • Practicability of Physostigmine/Hyoscine Pretreatment

  • Acceptability of Physostigmine/Hyoscine Pretreatment

  • Comparison of Pretreatment Approaches

  • Discussion and Conclusions

  • Summary and Longer Term Prospects

  • References