Chapter 5. Biological Markers of Exposure to Chemical Warfare Agents

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath3,4,5,
  2. Robert L. Maynard CBE, FRCP, FRCPath6 and
  3. Frederick R. Sidell MD7
  1. Robin M. Black1 and
  2. Daan Noort2

Published Online: 2 APR 2007

DOI: 10.1002/9780470060032.ch5

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

How to Cite

Black, R. M. and Noort, D. (2007) Biological Markers of Exposure to Chemical Warfare Agents, in Chemical Warfare Agents: Toxicology and Treatment, Second Edition (eds T. C. Marrs, R. L. Maynard and F. R. Sidell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470060032.ch5

Editor Information

  1. 3

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 4

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 5

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

  4. 6

    Health Protection Agency, Chilton, Didcot, Oxfordshire OX11 0RQ, UK

  5. 7

    US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA

Author Information

  1. 1

    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK

  2. 2

    TNO Defence, Security and Safety, PO Box 45, Rijswijk 2280 AA, The Netherlands

Publication History

  1. Published Online: 2 APR 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470013595

Online ISBN: 9780470060032

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Keywords:

  • riot control agents (RCAs) contravening CWC;
  • CW agents and biological markers of exposure;
  • sulphur and nitrogen mustards;
  • nerve agents - sarin (GB), VX and tabun (GA) Soman (GD) and cyclosarin (GF);
  • highly reactive phosgene electrophile

Summary

This chapter contains sections titled:

  • Introduction

  • Biological Reactions of CW Agents

  • Free Metabolites as Biological Markers

  • Protein and DNA Adducts as Biological Markers

  • Analytical Methods

  • Sulphur Mustard

  • Nitrogen Mustards

  • Lewisite

  • Nerve Agents

  • Quinuclidinyl Benzilate, BZ

  • Phosgene

  • Hydrogen Cyanide

  • Riot Control Agents

  • CS

  • CN

  • CR

  • Summary

  • References