Chapter 8. Toxicology of Organophosphate Nerve Agents

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath1,2,3,
  2. Robert L. Maynard CBE, FRCP, FRCPath4 and
  3. Frederick R. Sidell MD5
  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath1,2,3

Published Online: 2 APR 2007

DOI: 10.1002/9780470060032.ch8

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

How to Cite

Marrs, T. C. (2007) Toxicology of Organophosphate Nerve Agents, in Chemical Warfare Agents: Toxicology and Treatment, Second Edition (eds T. C. Marrs, R. L. Maynard and F. R. Sidell), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470060032.ch8

Editor Information

  1. 1

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 2

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 3

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

  4. 4

    Health Protection Agency, Chilton, Didcot, Oxfordshire OX11 0RQ, UK

  5. 5

    US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5400, USA

Author Information

  1. 1

    Edentox Associates, Pinehurst, Four Elms Road, Edenbridge, Kent TN8 6AQ, UK

  2. 2

    National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham B18 7QH, UK

  3. 3

    Lancashire School of Health and Postgraduate Medicine, University of Central Lancashire, Preston, PR1 2HE, UK

Publication History

  1. Published Online: 2 APR 2007
  2. Published Print: 23 MAR 2007

ISBN Information

Print ISBN: 9780470013595

Online ISBN: 9780470060032

SEARCH

Keywords:

  • organophosphate nerve agent toxicology;
  • acute toxicity;
  • cholinergic neurotransmission;
  • organophosphate-induced delayed polyneuropathy (OPIDP);
  • nerve agent-induced delayed polyneuropathy

Summary

This chapter contains sections titled:

  • Introduction

  • Toxicology

  • Effects on Specific Organs

  • Effect of Route of Exposure

  • Sub-Groups Particularly Liable to Nerve Agents

  • Laboratory Investigations

  • Diagnosis Post-Mortem

  • Reference Doses/Health-Based Guidance Values for Nerve Agents

  • Conclusions

  • References