Statistical Issues in Vaccine Safety Evaluation
Published Online: 15 MAR 2008
Copyright © 2007 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Statistics in Quality and Reliability
How to Cite
Farrington, C. P., Whitaker, H. J. and Hocine, M. N. 2008. Statistical Issues in Vaccine Safety Evaluation. Encyclopedia of Statistics in Quality and Reliability. IV.
- Published Online: 15 MAR 2008
This article describes some of the main statistical methods used to evaluate the safety of vaccines. The methods are illustrated using examples of public health concerns that arose following claims of associations, both real and unproven, between vaccination and adverse events. Prelicensure evaluation, surveillance methods, and observational study designs including case-control, cohort, and case-only methods are discussed.
- case-control study;
- case series;
- cohort study;
- randomized controlled trial;