19. Mapping Quantitative Trait Loci in Outbred Pedigrees

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. I. Höschele

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch19

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Höschele, I. (2007) Mapping Quantitative Trait Loci in Outbred Pedigrees, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch19

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Virginia Bioinformatics Institute and Department of Statistics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • phase-known QTL genotypes;
  • variance-components method;
  • IBD – identity-by-descent matrix;
  • phenotypes log-likelihood function;
  • Bayesian analysis;
  • Mendelian disease genes;
  • normal-inverse-gamma prior;
  • finite polygenic model;
  • multivariate normal distribution;
  • modified transmission probabilities

Summary

This chapter contains sections titled:

  • Introduction

  • Linkage Mapping via Least Squares or Maximum Likelihood and Fixed Effects Models

  • Linkage Mapping via Residual Maximum Likelihood and Random Effects Models

  • Linkage Mapping via Bayesian Methodology

  • Deterministic Haplotyping In Complex Pedigrees

  • Genotype Sampling In Complex Pedigrees

  • Fine Mapping of Quantitative Trait Loci

  • Concluding Remarks

  • Acknowledgments

  • References