2. Statistical Significance in Biological Sequence Comparison

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. W. R. Pearson and
  2. T. C. Wood

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch2

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Pearson, W. R. and Wood, T. C. (2008) Statistical Significance in Biological Sequence Comparison, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch2

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Department of Biochemistry, University of Virginia, Charlottesville, VA, USA

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

SEARCH

Keywords:

  • archebacterial genome;
  • prokaryotic and eukaryotic proteins;
  • molecular homology;
  • E. coli transcription termination factor;
  • accepted point mutation;
  • aligned amino acid residues;
  • membrane-spanning protein;
  • Caenorhabditis elegans;
  • unrelated and low-complexity sequences;
  • randomly shuffled human histone

Summary

This chapter contains sections titled:

  • Introduction

  • Statistical Significance and Biological Significance

  • Estimating Statistical Significance for Local Similarity Searches

  • Summary: Exploiting Statistical Estimates

  • Acknowledgments

  • References