27. Linkage Disequilibrium, Recombination and Selection

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. G. McVean

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch27

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

McVean, G. (2007) Linkage Disequilibrium, Recombination and Selection, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch27

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Department of Statistics, Oxford University, Oxford, UK

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • linkage disequilibrium;
  • single nucleotide polymorphism;
  • haplotype blocks;
  • population crossover rate;
  • recombination hotspots;
  • molecular processes – mutation and recombination;
  • identity by descent;
  • coalescent modelling;
  • ARG – ancestral recombination graph;
  • genealogical history

Summary

This chapter contains sections titled:

  • What Is Linkage Disequilibrium?

  • Measuring Linkage Disequilibrium

  • Modelling LD and Genealogical History

  • Inference

  • Prospects

  • Acknowledgments

  • Related Chapters

  • References