33. Linkage Analysis

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. E. A. Thompson

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch33

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Thompson, E. A. (2007) Linkage Analysis, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch33

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Department of Statistics, University of Washington, Seattle, WA, USA

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619



  • gene ordering inference;
  • Hardy–Weinberg equilibrium;
  • human genetic linkage analysis;
  • Mendelian segregation and linkage relationships;
  • DNA markers;
  • interconnected pedigree loops;
  • Monte Carlo multipoint linkage likelihoods;
  • complex traits linkage analysis;
  • maximum likelihood estimates


This chapter contains sections titled:

  • Introduction

  • The Early Years

  • The Development of Human Genetic Linkage Analysis

  • The Pedigree Years; Segregation and Linkage Analysis

  • Likelihood and Location Score Computation

  • Monte Carlo Multipoint Linkage Likelihoods

  • Linkage Analysis of Complex Traits

  • Map Estimation, Map Uncertainty, and The Meiosis Model

  • The Future

  • Acknowledgments

  • References