34. Non-Parametric Linkage

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. P. Holmans

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch34

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Holmans, P. (2007) Non-Parametric Linkage, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch34

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Department of Psychological Medicine, Cardiff University, Cardiff, UK

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619



  • identical by descent;
  • Mendelian inheritance laws;
  • individual pedigrees;
  • Hardy–Weinberg disequilibrium;
  • likelihood-ratio methods;
  • weighted pairwise correlation method;
  • logistic-regression linkage analysis;
  • genome search meta-analysis


This chapter contains sections titled:

  • Introduction

  • Pros and Cons of Model-free Methods

  • Model-free Methods for Dichotomous Traits

  • Model-free Methods for Analysing Quantitative Traits

  • Conclusions

  • Related Chapters

  • References