35. Population Admixture and Stratification in Genetic Epidemiology

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. P. M. McKeigue

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch35

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

McKeigue, P. M. (2007) Population Admixture and Stratification in Genetic Epidemiology, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch35

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Conway Institute, University College Dublin, Dublin, Ireland

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • Mendelian disease locus disequilibrium mapping;
  • ancestry-specific allele frequencies;
  • ethnic variation in disease risk;
  • non-insulin-dependent diabetes;
  • hidden Markov model;
  • expectation-maximization algorithm;
  • population stratification modelling;
  • ancestry-informative markers

Summary

This chapter contains sections titled:

  • Background

  • Admixture Mapping

  • Statistical Models

  • Testing For Linkage With Locus Ancestry

  • Conclusions

  • References