38. Family-Based Association

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. F. Dudbridge

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch38

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Dudbridge, F. (2007) Family-Based Association, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch38

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. MRC Biostatistics Unit, Institute for Public Health, Cambridge, UK

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • causal genetic variant;
  • haplotype-based haplotype relative risk;
  • transmission disequilibrium test;
  • parental chromosomes haplotype distribution;
  • logistic regression model;
  • maternal–foetal genotype interactions;
  • exchangeable parental genotypes;
  • identity-by-descent

Summary

This chapter contains sections titled:

  • Introduction

  • Transmission/Disequilibrium Test

  • Logistic Regression Models

  • Haplotype Analysis

  • General Pedigree Structures

  • Quantitative Traits

  • Association in the Presence of Linkage

  • Conclusions

  • References