6. Analysis of Microarray Gene Expression Data

  1. D. J. Balding3,
  2. M. Bishop4 and
  3. C. Cannings5
  1. W. Huber1,
  2. A. von Heydebreck2 and
  3. M. Vingron2

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch6

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Huber, W., von Heydebreck, A. and Vingron, M. (2007) Analysis of Microarray Gene Expression Data, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch6

Editor Information

  1. 3

    Imperial College of Science, Technology and Medicine, London, UK

  2. 4

    CNR-ITB, Milan, Italy

  3. 5

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. 1

    Department of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany

  2. 2

    Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Berlin, Germany

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • polymerase chain reaction;
  • variance-stabilizing transformation;
  • microarray technologies;
  • nonpositive intensity measurements;
  • maximum likelihood estimator;
  • biological variability;
  • gene-specific standard deviation estimate;
  • orthogonal linear combinations;
  • affine-linear transformations;
  • microarray gene expression data analysis

Summary

This chapter contains sections titled:

  • Introduction

  • Data Visualization and Quality Control

  • Error Models, Calibration and Measures of Differential Expression

  • Identification of Differentially Expressed Genes

  • Pattern Discovery

  • Conclusions

  • Acknowledgments

  • References