7. Statistical Inference for Microarray Studies

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. S. B. Pounds,
  2. C. Cheng and
  3. A. Onar

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch7

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Pounds, S. B., Cheng, C. and Onar, A. (2007) Statistical Inference for Microarray Studies, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch7

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619



  • phenotype-association analyses;
  • probe-set expression signals;
  • model-based normalization methods;
  • ratio-intensity plot;
  • polymerase chain reaction;
  • pooled p-value filter;
  • gene-specific data and variance;
  • therapy-related malignancy;
  • Bonferroni procedure;
  • therapy-related myeloid leukemia


This chapter contains sections titled:

  • Introduction

  • Initial Data Processing

  • Testing the Association of Phenotype with Expression

  • Multiple Testing

  • Annotation Analysis

  • Validation Analysis

  • Study Design and Sample Size

  • Discussion

  • Related Chapters

  • References