9. Inferring Causal Associations between Genes and Disease via the Mapping of Expression Quantitative Trait Loci

  1. D. J. Balding2,
  2. M. Bishop3 and
  3. C. Cannings4
  1. S. K. Sieberts and
  2. E. E. Schadt

Published Online: 9 MAY 2008

DOI: 10.1002/9780470061619.ch9

Handbook of Statistical Genetics, Third Edition

Handbook of Statistical Genetics, Third Edition

How to Cite

Sieberts, S. K. and Schadt, E. E. (2008) Inferring Causal Associations between Genes and Disease via the Mapping of Expression Quantitative Trait Loci, in Handbook of Statistical Genetics, Third Edition (eds D. J. Balding, M. Bishop and C. Cannings), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470061619.ch9

Editor Information

  1. 2

    Imperial College of Science, Technology and Medicine, London, UK

  2. 3

    CNR-ITB, Milan, Italy

  3. 4

    Division of Genomic Medicine, University of Sheffield, Sheffield, UK

Author Information

  1. Rosetta Inpharmatics, LLC, Seattle, WA, USA

Publication History

  1. Published Online: 9 MAY 2008
  2. Published Print: 24 AUG 2007

ISBN Information

Print ISBN: 9780470058305

Online ISBN: 9780470061619

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Keywords:

  • eQTL – expression quantitative trait loci;
  • messenger ribonucleic acid;
  • cis-acting elements;
  • transcription factor binding–associated proteins;
  • allelic or genotypic effects;
  • false discovery rate;
  • RNA expression traits;
  • genetic marker;
  • scale-free property;
  • genetic and molecular profiling data

Summary

This chapter contains sections titled:

  • Introduction

  • An Overview of Transcription as a Complex Process

  • Human Versus Experimental Models

  • Heritability of Expression Traits

  • Joint eQTL Mapping

  • Multilocus Models AND FDR

  • eQTL and Clinical Trait Linkage Mapping to Infer Causal Associations

  • Using eQTL Data to Reconstruct Coexpression Networks

  • Using eQTL Data to Reconstruct Probabilistic Networks

  • Conclusions

  • Software

  • References