Chapter 13. The Heart

  1. Patrizia Ferretti4,
  2. Andrew Copp4,
  3. Cheryll Tickle5 and
  4. Gudrun Moore6
  1. Deborah Henderson1,
  2. Mary R. Hutson2 and
  3. Margaret L. Kirby3

Published Online: 25 JAN 2010

DOI: 10.1002/9780470090121.ch13

Embryos, Genes and Birth Defects, Second Edition

Embryos, Genes and Birth Defects, Second Edition

How to Cite

Henderson, D., Hutson, M. R. and Kirby, M. L. (2008) The Heart, in Embryos, Genes and Birth Defects, Second Edition (eds P. Ferretti, A. Copp, C. Tickle and G. Moore), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9780470090121.ch13

Editor Information

  1. 4

    Neural Development Unit/Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

  2. 5

    Division of Cell and Developmental Biology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee, UK

  3. 6

    Clinical and Molecular Genetics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Author Information

  1. 1

    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, UK

  2. 2

    Neonatal–Perinatal Research Institute, Department of Pediatrics (Neonatology), Room 157, Bell Building, Duke University Medical Center, Durham, NC 27712, USA

  3. 3

    Neonatal–Perinatal Research Institute, Department of Pediatrics (Neonatology), Box 3179, Room 157, Bell Building, Duke University Medical Center, Durham, NC, 27712, USA

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470090107

Online ISBN: 9780470090121

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Keywords:

  • heart;
  • myocardium, endocardium, epicardium and neural crest-derived ectomesenchymal cells;
  • pharyngeal mesenchyme - source of secondary heart field myocardium;
  • cardiac induction, differentiating lateral plate mesoderm cells into myocardium;
  • retinoic acid - acting as morphogen, posterior polarity within heart tube;
  • chamber septation;
  • aortic atresia;
  • double-outlet right ventricle (DORV);
  • heparan sulphate proteoglycan (HSPG2)

Summary

This chapter contains sections titled:

  • Developmental anatomy

  • Major cell populations needed for heart development

  • Molecular regulation of heart development

  • Cardiovascular defects

  • The future

  • References