Chapter 15. The Vertebral Column

  1. Patrizia Ferretti1,
  2. Andrew Copp1,
  3. Cheryll Tickle2 and
  4. Gudrun Moore3
  1. David Rice and
  2. Susanne Dietrich

Published Online: 25 JAN 2010

DOI: 10.1002/9780470090121.ch15

Embryos, Genes and Birth Defects, Second Edition

Embryos, Genes and Birth Defects, Second Edition

How to Cite

Rice, D. and Dietrich, S. (2008) The Vertebral Column, in Embryos, Genes and Birth Defects, Second Edition (eds P. Ferretti, A. Copp, C. Tickle and G. Moore), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9780470090121.ch15

Editor Information

  1. 1

    Neural Development Unit/Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

  2. 2

    Division of Cell and Developmental Biology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee, UK

  3. 3

    Clinical and Molecular Genetics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470090107

Online ISBN: 9780470090121

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Keywords:

  • vertebral column;
  • nodal function, separating endodermal and mesodermal lineages;
  • retinoic acid - principal biologically active form of Vitamin A;
  • paraxial mesoderm segmentation;
  • epithelial somite formation;
  • zinc finger transcription factor Gli2 - activator of Shh targets in medial sclerotome;
  • sclerotome - vertebral, body pedicle, neural arch, proximal and distal rib formation;
  • sclerotomal subdomain specification - neural arch, pedicle and proximal rib, vertebral body and intervertebral disc

Summary

This chapter contains sections titled:

  • Introduction

  • Developmental anatomy of the vertebral column

  • Making the vertebral column

  • Agenda for the future

  • References