Chapter 16. The Kidney

  1. Patrizia Ferretti2,
  2. Andrew Copp2,
  3. Cheryll Tickle3 and
  4. Gudrun Moore4
  1. Paul J. D. Winyard

Published Online: 25 JAN 2010

DOI: 10.1002/9780470090121.ch16

Embryos, Genes and Birth Defects, Second Edition

Embryos, Genes and Birth Defects, Second Edition

How to Cite

Winyard, P. J. D. (2008) The Kidney, in Embryos, Genes and Birth Defects, Second Edition (eds P. Ferretti, A. Copp, C. Tickle and G. Moore), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9780470090121.ch16

Editor Information

  1. 2

    Neural Development Unit/Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

  2. 3

    Division of Cell and Developmental Biology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee, UK

  3. 4

    Clinical and Molecular Genetics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Author Information

  1. Nephro-urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470090107

Online ISBN: 9780470090121

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Keywords:

  • kidney;
  • mammalian kidneys - functions for normal post-natal life;
  • nephrons, functioning units of mature mammalian kidneys;
  • glomeruli, comprising mesangial cells and matrix;
  • three pairs of ‘kidneys’ in mammalian embryo - pronephros, mesonephros and metanephros;
  • pronephros - from 10-somite stage on day 22 in humans;
  • mesonephros - mesonephric duct and adjacent mesonephric tubules;
  • renal malformations - congenital abnormalities, complexity of normal development;
  • nephrogenesis - balancing basic cellular and tissue processes;
  • transcription factors - conductors of nephrogenic chorus

Summary

This chapter contains sections titled:

  • Introduction

  • Structure and function

  • Developmental anatomy of nephrogenesis

  • Transcription factors

  • Growth factors and their receptors

  • Survival/proliferation factors

  • Cell adhesion molecules

  • Other molecules

  • Non-genetic causes of renal malformations

  • Agenda for the future

  • Conclusion

  • References