Chapter 8. Brain and Spinal Cord

  1. Patrizia Ferretti1,
  2. Andrew Copp1,
  3. Cheryll Tickle2 and
  4. Gudrun Moore3
  1. Andrew J. Copp

Published Online: 25 JAN 2010

DOI: 10.1002/9780470090121.ch8

Embryos, Genes and Birth Defects, Second Edition

Embryos, Genes and Birth Defects, Second Edition

How to Cite

Copp, A. J. (2008) Brain and Spinal Cord, in Embryos, Genes and Birth Defects, Second Edition (eds P. Ferretti, A. Copp, C. Tickle and G. Moore), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9780470090121.ch8

Editor Information

  1. 1

    Neural Development Unit/Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

  2. 2

    Division of Cell and Developmental Biology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee, UK

  3. 3

    Clinical and Molecular Genetics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Author Information

  1. Neural Development Unit/Developmental Biology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470090107

Online ISBN: 9780470090121

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Keywords:

  • brain and spinal cord;
  • neural tube - embryonic progenitor of brain and spinal cord;
  • regional patterning - latent potential for differentiation;
  • anterior hindbrain neural tube - cells forming cerebellar Purkinje neurons;
  • early migrating neuroblasts - forming transient structure;
  • defective nervous system development;
  • holoprosencephaly - neural induction and dorso-ventral forebrain patterning defects;
  • open spina bifida - mouse mutants exhibiting low spinal neurulation defects;
  • rostro-caudal neural patterning defects in humans and cerebellar agenesis;
  • neuronal migration disorders

Summary

This chapter contains sections titled:

  • Introduction

  • Overview of nervous system development

  • Defects of CNS development: towards a genetic and developmental understanding

  • Agenda for the future

  • References