Chapter 1. The Reaction Mechanisms of Zinc Enzymes

  1. Professor Zvi Rappoport3 and
  2. Ilan Marek4
  1. Gudrun Schürer1,
  2. Timothy Clark1 and
  3. Rudi van Eldik2

Published Online: 4 SEP 2007

DOI: 10.1002/9780470093399.ch1

The Chemistry of Organozinc Compounds

The Chemistry of Organozinc Compounds

How to Cite

Schürer, G., Clark, T. and van Eldik, R. (2006) The Reaction Mechanisms of Zinc Enzymes, in The Chemistry of Organozinc Compounds (eds Z. Rappoport and I. Marek), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470093399.ch1

Editor Information

  1. 3

    The Hebrew University, Jerusalem, Israel

  2. 4

    Technion-Israel Institute of Technology, Haifa, Israel

Author Information

  1. 1

    Computer Chemistry Center, University of Erlangen-Nürnberg, Nägelsbachstr. 25, D-91052 Erlangen, Germany

  2. 2

    Institute for Inorganic Chemistry, University of Erlangen-Nürnberg, Egerlandstr. 1, D-91058 Erlangen, Germany

Publication History

  1. Published Online: 4 SEP 2007
  2. Published Print: 27 OCT 2006

Book Series:

  1. PATAI'S Chemistry of Functional Groups

Book Series Editors:

  1. Professor Saul Patai and
  2. Professor Zvi Rappoport

Series Editor Information

  1. The Hebrew University, Jerusalem, Israel

ISBN Information

Print ISBN: 9780470093375

Online ISBN: 9780470093399

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Keywords:

  • zinc enzyme reaction mechanisms;
  • zinc enzymes and synthetic model complexes;
  • zinc hydrolase superfamily;
  • Aeromonas proteolytica aminopeptidase (AAP);
  • C–N bond cleavage step;
  • bovine lens leucyl aminopeptidase (blLAP);
  • QM/MM techniques;
  • Lipscomb and Lindskog mechanisms or proton-transfer step;
  • active-site water molecules

Summary

This chapter contains sections titled:

  • Introduction

  • Structural Aspects

  • General Reaction Mechanisms

  • A Number of Enzymes

  • Acknowledgment

  • References