Chapter 5. Protein Networks and Protein Phosphorylation in Cancer

  1. Mahmoud H. Hamdan

Published Online: 1 AUG 2006

DOI: 10.1002/9780470113127.ch5

Cancer Biomarkers: Analytical Techniques for Discovery

Cancer Biomarkers: Analytical Techniques for Discovery

How to Cite

Hamdan, M. H. (2007) Protein Networks and Protein Phosphorylation in Cancer, in Cancer Biomarkers: Analytical Techniques for Discovery, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470113127.ch5

Author Information

  1. GlaxoSmithKline, Verona, Italy

Publication History

  1. Published Online: 1 AUG 2006
  2. Published Print: 26 JAN 2007

ISBN Information

Print ISBN: 9780471745167

Online ISBN: 9780470113127

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Keywords:

  • protein networks and protein phosphorylation in cancer;
  • protein interaction networks;
  • two-dimensional gel electrophoresis (2-DE)

Summary

This chapter contains sections titled:

  • Introduction

  • Protein Interaction Networks

  • Computational Approaches

  • Human Protein Intractome

  • Relationship Between Gene Expression and Protein Interaction

  • Gene Signatures in Cancer Prediction/Classification

  • Concluding Remarks

  • Protein Phosphorylation

  • Other Approaches

  • The Phosphatidylinositol 3-Kinase-Akt Pathway (PI3K-Akt)

  • PIK3/Akt Alterations and Prognostic Biomarkers

  • General Observations

  • References