The Behavior and Significance of Slow-Binding Enzyme Inhibitors

  1. Alton Meister
  1. John F. Morrison1,
  2. Christopher T. Walsh2,†

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123072.ch5

Book Title

Advances in Enzymology and Related Areas of Molecular Biology, Volume 61

Advances in Enzymology and Related Areas of Molecular Biology, Volume 61

Additional Information

How to Cite

Morrison, J. F. and Walsh, C. T. (2006) The Behavior and Significance of Slow-Binding Enzyme Inhibitors, in Advances in Enzymology and Related Areas of Molecular Biology, Volume 61 (ed A. Meister), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123072.ch5

Editor Information

  1. Cornell University Medical College, New York, New York

Author Information

  1. 1

    Department of Biochemistry, John Curtin School of Medical Research, Australian National University, Canberra, Australia

  2. 2

    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

  1. †

    Current Address: Dept. Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Ma 02115.

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 1988

ISBN Information

Print ISBN: 9780471818304

Online ISBN: 9780470123072

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CHAPTER TOOLS

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Keywords:

  • slow-binding enzyme inhibitors;
  • progress curves;
  • slow catalytic turnover;
  • hexokinase inhibition;
  • methotrexate inhibition

Summary

  • Introduction

  • Characteristics of Progress Curves for Slow-Binding Inhibitors

  • Specific Cases of Slow-Binding Inhibition

  • Concluding REmarks

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