Molecular, Thermodynamic, and Biological Aspects of Recognition and Function in Neurophysin-Hormone Systems: A Model System for the Analysis of Protein–Peptide Interactions

  1. Alton Meister
  1. Esther Breslow,
  2. Sudhir Burman

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123096.ch1

Advances in Enzymology and Related Areas of Molecular Biology, Volume 63

Advances in Enzymology and Related Areas of Molecular Biology, Volume 63

How to Cite

Breslow, E. and Burman, S. (2006) Molecular, Thermodynamic, and Biological Aspects of Recognition and Function in Neurophysin-Hormone Systems: A Model System for the Analysis of Protein–Peptide Interactions, in Advances in Enzymology and Related Areas of Molecular Biology, Volume 63 (ed A. Meister), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123096.ch1

Editor Information

  1. Cornell University Medical College, New York, New York

Author Information

  1. Department of Biochemistry, Cornell University Medical College, New York, New York

  1. Present address: Smith Kline and French, King of Prussia, PA 19406-0939.

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 1990

ISBN Information

Print ISBN: 9780471509844

Online ISBN: 9780470123096

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Keywords:

  • neurophysin-hormone systems;
  • protein-peptide interactions;
  • hormone-bonding interactions;
  • thermodynamic analysis;
  • allosteric mechanisms

Summary

This chapter contains sections titled:

  • Introduction

  • Primary Structures of Components of the Neurophysin–Hormone System: Relationship to Gene Structure and Evolution

  • Processing of Neurophysin Precursors

  • Functions within the Neurophysin–Hormone System

  • Chemical Properties of Neurophysins, Neurophysin–Hormone Complexes, and Their Common Precursors: An Overview

  • Hormone Bonding Interactions within Neurophysin–Hormone Complexes

  • Thermodynamic Analysis of Bonding in Neurophysin Complexes

  • Conformation of Neurophysin and Organization of Its Binding Site

  • Allosteric Mechanisms Associated with Neurophysin-Hormone and Neurophysin-Peptide Interactions

  • Conformational, Bonding, and Self-Association Properties of Neurophysin Precursors

  • Perspectives