Insulin and the Stimulation of Glycogen Synthesis. The Road from Glycogen Structure to Glycogen Synthase to Cyclic Amp-Dependent Protein Kinase to Insulin Mediators
- Alton Meister
Published Online: 22 NOV 2006
DOI: 10.1002/9780470123096.ch3
Copyright © 1990 by John Wiley & Sons, Inc.
Book Title
Advances in Enzymology and Related Areas of Molecular Biology, Volume 63
Additional Information
How to Cite
Larner, J. (2006) Insulin and the Stimulation of Glycogen Synthesis. The Road from Glycogen Structure to Glycogen Synthase to Cyclic Amp-Dependent Protein Kinase to Insulin Mediators, in Advances in Enzymology and Related Areas of Molecular Biology, Volume 63 (ed A. Meister), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123096.ch3
Editor Information
Cornell University Medical College, New York, New York
Publication History
- Published Online: 22 NOV 2006
- Published Print: 1 JAN 1990
ISBN Information
Print ISBN: 9780471509844
Online ISBN: 9780470123096
- Summary
- Chapter
- References
Keywords:
- glycogen synthesis stimulation;
- glycogen synthase;
- cyclic-amp-dependent protein kinase;
- insulin mediators;
- phosphoprotein phosphatases
Summary
This chapter contains sections titled:
Introduction
Historical
Biochemical Considerations and a Glycogen-K+ Pump Hypothesis
Integration of Covalent and Allosteric Controls of Phosphorylase and Glycogen Synthase
Phosphorylation Sites of Glycogen Synthase
Emerging Significance of Multiple Phosphorylation
Decreased Phosphorylation of Glycogen Synthase with Insulin Action
Insulin and Established Second Messengers
Stable and Allosteric Effects of Insulin on Protein Kinases
Short- and Long-Term Effects of Insulin on Phosphoprotein Phosphatases
Two Pathways for Activation of Glycogen Synthase by Insulin
Purification and Action of Two Mediators-A Mechanism for Dephosphory lation
Formation of lnsulin Mediators
Insulin Receptor Activation and Mediator Formation
Summary