Aspartate Transcarbamylase from Escherichia Coli: Activity and Regulation

  1. Alton Meister
  1. William N. Lipscomb

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123140.ch3

Advances in Enzymology and Related Areas of Molecular Biology, Volume 68

Advances in Enzymology and Related Areas of Molecular Biology, Volume 68

How to Cite

Lipscomb, W. N. (2006) Aspartate Transcarbamylase from Escherichia Coli: Activity and Regulation, in Advances in Enzymology and Related Areas of Molecular Biology, Volume 68 (ed A. Meister), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123140.ch3

Editor Information

  1. Cornell University Medical Colloge, New York, New York

Author Information

  1. Department of Chemistry, Harvard University, Cambridge, MA

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 1994

ISBN Information

Print ISBN: 9780471310716

Online ISBN: 9780470123140

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Keywords:

  • aspartate transcarbamylase;
  • negative cooperativity;
  • UTP activation;
  • domain closure;
  • subunit structure

Summary

  • Introduction

  • Subunit Structure

  • Activity and Regulation: Illustrative Biochemical Studies

  • Structural Results and Catalysis

  • Domain Closure and Homotropic Effects

  • Asymmetry and Negative Cooperativity

  • Structural Aspects of Heterotropic Effects

  • Biochemical and Other Mutant Studies of Heterotropic Effects

  • Pathways

  • Heterotropic Effects: General Summary