Mechanistic Issues in Asparagine Synthetase Catalysis

  1. Daniel L. Purich
  1. Nigel G. J. Richards1,
  2. Sheldon M. Schuster2

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123188.ch5

Book Title

Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72

Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72

Additional Information

How to Cite

Richards, N. G. J. and Schuster, S. M. (2006) Mechanistic Issues in Asparagine Synthetase Catalysis, in Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72 (ed D. L. Purich), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123188.ch5

Editor Information

  1. University of Florida College of Medicine, Gainesville, Florida

Author Information

  1. 1

    Department of Chemistry, University of Florida, Gainesville, FL 32611

  2. 2

    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, and Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32611

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 1998

ISBN Information

Print ISBN: 9780471246435

Online ISBN: 9780470123188

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CHAPTER TOOLS

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Keywords:

  • asparagine synthetase catalysis;
  • aspartic acid activation;
  • glutamine-dependent nitrogen transfer;
  • imide intermediate;
  • aspartic acid binding site identification

Summary

  • Introduction

  • Background

  • Structure of Glutamine-Dependent Asparagine Synthetases

  • Mechanism of Aspartic Acid Activation

  • Molecular Mechanisms of Glutamine-Dependent Nitrogen Transfer

  • Conclusions

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