Mechanisms of Cysteine S-conjugate β-Lyases

  1. Daniel L. Purich
  1. Arthur J. L. Cooper

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123188.ch6

Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72

Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72

How to Cite

Cooper, A. J. L. (2006) Mechanisms of Cysteine S-conjugate β-Lyases, in Advances in Enzymology and Related Areas of Molecular Biology: Amino Acid Metabolism, Part A, Volume 72 (ed D. L. Purich), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123188.ch6

Editor Information

  1. University of Florida College of Medicine, Gainesville, Florida

Author Information

  1. Departments of Biochemistry and of Neurology and Neuroscience, Cornell University Medical College, New York 10021 and Burke Medical Research Institute, Cornell University Medical College, White Plains, NY 10605

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 1998

ISBN Information

Print ISBN: 9780471246435

Online ISBN: 9780470123188

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Keywords:

  • γ-glutamyl transpeptidase;
  • gene structure and expression;
  • glutathione metabolism;
  • catalytic & active site chemistry;
  • substrate specificity

Summary

  • Introduction

  • Discovery

  • Toxicity of Cysteine S-Conjugates

  • Relationship of Cysteine S-Conjugate β-Lyases to Other Enzymes That Catalyze β-Elimination Reactions

  • Cysteine S-Conjugate β-Lyases in Bacteria and Fungi

  • Mammalian Cysteine S-Conjugate β-Lyases

  • Cysteine S-Conjugate β-Lyases as Targets for Prodrugs Targeted to the Kidney

  • Conclusions